Petros Efthimiou is a Board Certified Specialist in Rheumatology at the rank of Clinical Professor of Medicine & Rheumatology in New York City. A summa cum laude graduate of the University of Ioannina Medical School in Greece, Dr. Efthimiou became a Research Scholar at Northwestern University College of Medicine in Chicago, Illinois. He then completed his Internal Medicine Residency at Brown University in Providence, Rhode Island, while his Rheumatology Fellowship took place at the Hospital for Special Surgery and New York Presbyterian/Cornell Campus. Dr. Efthimiou has expertise in the treatment of autoimmune disorders including Rheumatoid Arthritis, Psoriatic arthritis, gout, osteoarthritis, myositis, SLE-lupus, Sjogren’s syndrome, Vasculitis, Pulmonary Hypertension, Scleroderma, Osteoporosis, Auto-inflammatory Syndromes and Adult Still’s Disease. Dr. Efthimiou has published extensively in peer-reviewed journals and medical textbooks and has served as Clinical Investigator in multiple, international, randomized controlled trials. He has served as an ad hoc reviewer and editorial board member in peer-reviewed rheumatology journals and is a frequently invited speaker in national and international medical conferences. He has extensive experience as an Expert Witness in medicolegal cases. A 2011-20 “Castle Connolly” and “US News & World Report”, Top Doctor in Rheumatology, he was the recipient of the Patients’ Choice Award in 2012-20 and named a 2014-20 “Super Doctor” by the New York Times and “Best Doctor” by New York Magazine. He has published a medical textbook in the Auto-inflammatory Syndromes and a Rheumatology Review Textbook.rnDr Efthimiou is Board Certified in Rheumatology and Internal Medicine.
Medical Record Review
Hospital for Special Surgery - New York, NY, USA
Certificate in Rheumatology
Diplomate of American Board of Internal Medicine (ABIM) in Internal Medicine & Rheumatology
Peer Reviewed Articles Musch MW, Mamah D, Gawenis LR, Zhang Z, Ellsworth W, Shalowitz D, Efthimiou P,…, Barrett TA. “T-cell activation causes diarrhea by increasing intestinal permeability and downregulating epithelial Na+/K+ATPase” Journal of Clinical Investigation, 2002, 110:1739-1747. Efthimiou P, Markenson JA. “Role of Biologic Agents in the Treatment of Immune Mediated Inflammatory Diseases”. Southern Medical Journal, 2005, 98(2): 192-204. Efthimiou P, Paik P, Bielory L. “Diagnosis and Management of Adult Onset Still’s Disease (AOSD)”. Annals of Rheumatic Diseases, 2006; 65: 564-572. Ramaswami R, Efthimiou P, Gnanasekaran I. “Musculoskeletal Manifestations of Dialysis; an update” Clinical Rheumatology, 2006 Jul;25(4):440-2. Efthimiou P, Schwartzman S, Kagen L “Possible Role for TNF-Inhibitors in the Treatment of Resistant Dermatomyositis and Polymyositis”. Annals of Rheumatic Diseases, 2006, Sep;65(9):1233-6. Rosenkranz ME, Agle LM, Efthimiou P, Lehman TJ. “Systemic and localized scleroderma in children: current and future treatment options”. Paediatric Drugs. 2006;8(2):85-97. Ogden NS, Ward CM, Kontzias A, Wyatt ST, and Efthimiou P. “Adult Onset Still Disease: 20 Clinical Pearls” Journal of Musculoskeletal Medicine, 2006; 23:788-800. Efthimiou P. “Tumor Necrosis Factor alpha in inflammatory myopathies: pathophysiology and therapeutic implications”. Seminars in Arthritis and Rheumatism, 2006 Dec; 36(3): 168-72. Efthimiou P and Georgy S.¨Pathophysiology and Management of Adult Onset Still’s Disease”. Seminars in Arthritis and Rheumatism, 2006 Dec; 36(3): 144-52. Efthimiou P and Sood S. “QuantiFERON TB Gold Test: the New Standard for Screening of Latent Tuberculosis in Patients with Rheumatoid Arthritis?” Annals of Rheumatic Diseases, 2007 Feb; 66(2):276 Blake AD, West FM, Ghafoor S, and Efthimiou P. “Somatostatin Involvement in Rheumatoid Arthritis” Current Rheumatology Reviews, 2007; 3:31-36. Efthimiou P,Ward MC, Kontzias A, Ogden NS. “Adult Onset Still’s disease: Can New Pathophysiologic Clues Guide Future Targeted Treatments?” Nature Reviews Rheumatology, 2007 Jun; 3(6): 328-335. Efthimiou P, Kumar S. “Development of Olecranon Bursitis after Treatment with Abatacept in a Patient with Rheumatoid Arthritis” Contemporary Topics in Rheumatoid Arthritis, 2007; 1(3): 6-8. Efthimiou P “Translating Basic Research Findings into Therapeutic Advances in Rare Rheumatologic Disorders: Lessons Learned from Adult Onset Still’s Disease” Contemporary Topics in Rheumatoid Arthritis, 2007; 1(4): 4-9. Efthimiou P, Blanco M. “Intravenous Gammaglobulin and Thalidomide may be an Effective Therapeutic Combination in Refractory Scleromyxedema” Seminars in Arthritis and Rheumatism, 2008 Dec;38(3):188-94 Kontzias A and Efthimiou P. “Adult-Onset Still’s Disease : Pathogenesis, Clinical Manifestations and Therapeutic Advances” Drugs, 2008; 68(3):319-337 Efthimiou P, Nasis O, Lehman TJ. “Aortic aneurysm in Takayasu’s arteritis” Journal of Rheumatology, 2007, Nov;34(11):2312. Yavari N, Platt H, Michel R, Navarro C, and Efthimiou P.” Environmental and Occupational Exposure in Rheumatoid Arthritis” Journal of Musculoskeletal Medicine, 2008; 25:130-136. Efthimiou P et al. “Autoinflammatory syndromes and infections: pathogenetic and clinical implications”. Clinical Experimental Rheumatology, 2008; Jan-Feb;26(1 Suppl 48):S53-61. Efthimiou P, Nasis O, Russell LA. “Classic presentation of a rare disease: melorheostosis”. Journal of Rheumatology, 2008 Jun;35(6):1169. Souayah N, Chodos A, Krivitskaya N, Efthimiou P, Lambert WC, Sharer LR. “Isolated severe vasculitic neuropathy revealing sarcoidosis”. Lancet Neurology. 2008 Aug;7(8):756-60. Efthimiou P.” Preoperative management of patients with rheumatoid arthritis underdoing elective surgery while being treated with abatacept”. Contemporary Topics in Rheumatoid Arthritis, 2008; 2(4):6-9. Efthimiou P, Blanco M. “Pathogenesis of Neuropsychiatric Systemic Lupus Erythematosus and Potential Biomarkers” Modern Rheumatology, 2009;19(5):457-68 Kukar M, Petryna O, and Efthimiou P. “Biological targets in the treatment of Rheumatoid arthritis: A Comprehensive review of Current and In-development Biological Disease Modifying Anti-Rheumatic Drugs”, Biologics:Targets &Therapy, 2009:3 443–457 Petryna O and Efthimiou P. “An Unusual Cause of Lower Back Pain”, Journal of Rheumatology, 2009 Nov;36(11):2556 Efthimiou P, Kukar M, Kagen LJ. “Severe Adult Onset Calcinosis in a patient with a history of Juvenile Dermatomyositis”, Journal of Rheumatology, 2010 Jan;37(1):194 Efthimiou P, Petryna O. ”Headache from Cavernous Sinus Thrombosis in Adamantiades-Behcet’s Disease”, Journal of Clinical Rheumatology, 2010; Dec;16(8):409 Efthimiou P, Kukar M. “Complementary and Alternative Medicine: Proposed mechanism of action and efficacy of commonly used modalities in Rheumatoid arthritis, A Comprehensive Review of the Recent Literature”, Rheumatology International; 2010 Mar; 30(5): 571-86 Efthimiou P, Kukar M. “Complementary and Alternative Medicine in Rheumatoid Arthritis: No Longer the Last Resort”, HSS Journal, 2010; 6: 108–111 Petryna O, Yavari N, Efthimiou P. “Occupational and Environmental Exposures in Lupus and Systemic Sclerosis: A preventable Risk Factor?” Journal of Musculoskeletal Medicine, 2010; 27:395-402. Efthimiou P, Kukar M, Krishnan P. “Posterior Reversible Encephalopathy Syndrome (PRES): a severe manifestation of neuropsychiatric systemic lupus erythematosus (NPSLE)” Arthritis and Rheumatism, 2010 Jun;62(6):1692. Efthimiou P, Petryna O, Kukar M, Gold M.” Characteristic neuroimaging findings in posterior reversible encephalopathy syndrome (PRES) in SLE: Reply.” Arthritis and Rheumatism, 2011 Jan; 63(1):309-10 Efthimiou P, Kukar, Hersh A. “Rituximab and Lupus Interstitial Lung Disease: Friend or Foe?” International Journal of Rheumatic Diseases, 2011 Feb; 14(1): e3-4. Efthimiou P, Pokharna H, Kukar M, Hennessey K. “PCP Chemoprophylaxis is Essential for Lymphopenic Dermatomyositis Patients Treated with Immunomodulators”, Muscle & Nerve, 2011 Jun; 43 (6):918-9. Efthimiou P, Kukar M. “Lupus Pernio: Sarcoid-specific Cutaneous Manifestation Associated with Chronic Sarcoid Arthropathy”, Journal of Clinical Rheumatology, 2011; 17 (6): 343. Mehta B and Efthimiou P. “Latent Tuberculosis in RA: The Disease and the Diagnosis”, Journal of Musculoskeletal Medicine, 2011; 28 (7): 249-55 Mehta B and Efthimiou P. “Latent Tuberculosis in RA: Current Diagnostic Techniques and Treatment”, Journal of Musculoskeletal Medicine, 2011; 28 (8): 300-307 Mehta B, Mueller W, and Efthimiou P. “CNS vasculitis: A protean manifestation of HIV/AIDS”, Journal of Musculoskeletal Medicine, 2011; 28 (12): 462-464 Mehta B and Efthimiou P. “Radiographic Improvement in Sarcoid Arthropathy after Infliximab Treatment”, Journal of Rheumatology, 2012; 39;664-5 Kukar M and Efthimiou P. “Therapeutic Armamentarium against Rheumatoid Arthritis in the New Decade: not there yet, but getting closer”, European Musculoskeletal Review; www.touchmusculoskeletal.com, May, 2012 Mehta B and Efthimiou P. “Ferritin in Adult onset Still’s disease (AOSD): just a useful innocent bystander?” International Journal of Inflammation, 2012; 2012:298405. Epub Mar 25 Kontzias A and Efthimiou P. “”The Use of Canakinumab, a Novel IL-1β Long Acting Inhibitor, in Refractory Adult-onset Still’s Disease.” Seminars in Arthritis and Rheumatism, 2012 Oct; 42(2):201-5. Petryna O, Cush JJ, and Efthimiou P. “IL-1 Trap Rilonacept in Refractory Adult-onset Still’s Disease”, Annals of Rheumatic Diseases, 2012; 71: 2056-2058 Efthimiou P, Moorthy N, Mavragani CP, Skokos D, Fautrel B “Editorial: Adult- onset Still’s Disease and Autoinflammation” International Journal of Inflammation, 2012:964751. Epub 2012 Aug 29 Hsieh J, Kadavath S, and Efthimiou P. “Can Traumatic Injury Trigger Psoriatic Arthritis?” Clinical Rheumatology, 2014 May;33(5):601-8. doi: 10.1007/s10067-013-2436-7 Kadavath S and Efthimiou P. “Canakinumab in Autoimmune and Autoinflammatory Rheumatic Diseases.” Expert Opinion on Orphan Drugs, Jan 2014, Vol. 2,1, pp 27-35. Efthimiou P, Kadavath S, Mehta B.”Life-threatening complications of adult-onset Still’s disease. Clinical Rheumatology. 2014 Mar;33(3):305-14. Kadavath S, Zapantis E, and Efthimiou P. “A Novel Therapeutic Approach In Adult Onset Still`s Disease- Associated Pulmonary Hypertension: Targeting Interleukin 6” International Journal of Rheumatic Diseases, 2014, International Journal of Rheumatic Diseases. 2014 Mar;17(3):336-40. Kadavath S and Efthimiou P.”Adult-onset Still’s disease-pathogenesis, clinical manifestations, and new treatment options” Annals of Medicine. 2015 Jan 22:1-9. Kadavath S, Bobic S, Efthimiou P. “Use of B lymphocyte stimulator inhibitor belimumab may be associated with a decrease in the serum concentration of epidermal growth factor in patients with primary Sjögren’s syndrome.” Clinical Rheumatology. 2015;34(9):1651-1652. Afzal A, Chittalai S,Wong I, Efthimiou P. “Unmasking IgG4-related autoimmune pancreatitis from pancreatic cancer: A lesson learned” Int J Case Rep Images. 2016;7(2):123–126. Ruiz-Irizarry Y and Efthimiou P. “Rhabdomyolysis and Polyarticular Inflammatory Arthritis May be the Initial Presentation of Chronic Myelogenous Leukemia (CML)”. J Rheum Dis Treat. 2015, 1:3 Mehta B, Zapantis E, Petryna O, Efthimiou P “Screening Optimization of Latent Tuberculosis Infection in Rheumatoid Arthritis Patients”. Arthritis, 2015;2015:569620. Levine T, Malone J, Efthimiou P, Tandan R, Dikranian A, Levine A, Saperstein D. “H.P.A.G in Dermatomyositis and Polymyositis Treatment Registry: An Interim Analysis” J Neurol Disord 2016, 4:5, DOI: 10.4172/2329-6895.1000292 Efthimiou P, Yadlapati S. “Impact of IL-1 inhibition on fatigue associated with Autoinflammatory syndromes” Modern Rheumatology. 2016; Jan;26(1):3-8. Yadlapati S, Efthimiou P. “Inadequate response or intolerability to oral methotrexate: Is it optimal to switch to subcutaneous methotrexate prior to considering therapy with biologics?” Rheumatology International. 2016 May;36(5):627-33. Yadlapati S, Efthimiou P. “Autoimmune/Inflammatory Arthritis Associated Lymphomas: Who Is at Risk?”. BioMed Research International, 2016; 2016: 8631061. Bello AE, Perkins EL, Jay R, Efthimiou P. “Recommendations for optimizing methotrexate treatment for patients with rheumatoid arthritis” Open Access Rheumatol. 2017 Mar 31;9:67-79. doi: 10.2147/OARRR.S131668. eCollection 2017. Yadlapati S, Efthimiou P. “IgG4-Related Disease: A Complex Under-Diagnosed Clinical Entity” Rheumatology International, 2018 Feb;38(2):169-177 Feist E, Quartier P, Fautrel B, Schneider R, Sfriso P, Efthimiou P, Cantarini L,,, Speziale. “Efficacy and safety of canakinumab in patients with Still’s disease: Exposure-response analysis of pooled SJIA data by age groups”, Clin Exp Rheumatology, 2018 Jul-Aug;36(4):668-675. Epub 2018 Mar 2 Menon S and Efthimiou P. “Tumor necrosis factor receptor associated periodic syndrome (TRAPS) in adults” Rheumatology International, 2018 Jan;38(1):3-11 Chao R, Das M, Philip C, Efthimiou P “Oxygen-Dependent Patient with Antisynthetase Syndrome Associated Interstitial Lung Disease Responds Promptly to Rituximab with Rapid Pulmonary Function Improvement” Mediterr J Rheumatol 2017; 28(3):56-59 Bottai M, Tjärnlund A, Santoni G…Efthimiou P… et al. International Myositis Classification Criteria Project consortium, the Euromyositis register and the Juvenile Dermatomyositis Cohort Biomarker Study and Repository (JDRG) (UK and Ireland) “EULAR/ACR classification criteria for adult and juvenile idiopathic inflammatory myopathies and their major subgroups: a methodology report” RMD Open. 2017 Nov 14;3(2):e000507. doi: 10.1136/rmdopen-2017-000507. eCollection 2017. Chao R, Ivanov A, Efthimiou P.”Cardiac Magnetic Resonance Imaging of Cardiac Amyloidosis”. J Clin Rheumatol. 2019 Aug;25(5):e59-e60 Mehta BY, Ibrahim S, Briggs W, Efthimiou P. “Racial/Ethnic variations in morbidity and mortality in Adult Onset Still’s Disease: An analysis of national dataset” Semin Arthritis Rheum. 2019 Apr 25. pii: S0049-0172(19)30123-4. doi: 10.1016/j.semarthrit.2019.04.004. [Epub ahead of print] Books, Monographs and Chapters Efthimiou P and Paget SA. “Rheumatoid Arthritis”. Chapter in: Hospital Healthcare Europe 2003/2004, P38-39, Healthcare Publications, 2003, Campden Publishing, London, UK Schwartzman S and Efthimiou P. “Progressive Systemic Sclerosis (PSS) and Related Disorders”. Chapter in: American College of Physicians (ACP) Expert Guide to Rheumatology, 2005, pp135-147, ACP Publications, Philadelphia, PA. Efthimiou P and Kagen L. “Polymyositis, Dermatomyositis, and Inclusion Body Myositis”. Chapter in: Manual of Rheumatology and Outpatient Orthopedic Disorders: Diagnosis and Therapy, Fifth Edition, 2005, pp 245-252, Lippincott, Williams & Wilkins, New York, NY Efthimiou P and Markenson J. “Psoriatic Arthritis”. Chapter in: Manual of Rheumatology and Outpatient Orthopedic Disorders: Diagnosis and Therapy, Fifth Edition, 2005, pp 318-24, Lippincott Williams & Wilkins, New York, NY Efthimiou P. “Rheumatology”. Chapter in: Last Minute: Internal Medicine, Miksad, R. Meyer, K. and Delamora, P. McGraw-Hill. NY, NY 2008 Efthimiou P, Petryna O, Kukar M. “Complex situations in patients with adult-onset Still disease” in Autoimmune Diseases: Complex and Acute Situations, 2011, pp 221-232, Springer, NY, NY. Kontzias A, Efthimiou P. Adult-Onset Still’s Disease in Baliga RR (editor). Textbook of Internal Medicine:An Intensive Board Review Book with 1480 Multiple Choice Questions 1st Kindle Edition, Blendon-Miller, An imprint of MasterMedFacts LLC, March 2018 Efthimiou P, Kontzias A. “Treatment of Rheumatoid Arthritis” chapter in: Encyclopedia of Medical Immunology, Eds: Ian R.Mackay, Noel R. Rose, Springer, NY, NY, 2014. Yadlapati S, Efthimiou P. “Cyclic Neutropenia”, chapter in: 5-minute clinical consult, 26th, 27th, 28th Eds, Ed: Frank J. Domino, Wolters Kluwer, NY, 2018-20. Yadlapati S, Efthimiou P. “Adult Onset Still’s Disease”, chapter in: Auto-Inflammatory Syndromes: Pathophysiology, Diagnosis, and Management, Springer-Nature, NY, 2019. Mehta B, Efthimiou P. “Macrophage Activation Syndrome”, chapter in: Auto-Inflammatory Syndromes: Pathophysiology, Diagnosis, and Management, Springer-Nature, NY, 2019. Ruiz-Fernandez R, Efthimiou P. “Clinical Genetics in Rheumatology”, chapter in: Absolute Rheumatology Review, Springer-Nature, NY, 2019. Efthimiou P, Editor-in-Chief, Textbook, Auto-Inflammatory Syndromes: Pathophysiology, Diagnosis, and Management, Springer-Nature, NY, 2019. Efthimiou P, Editor-in-Chief, Textbook, Absolute Rheumatology Review, Springer-Nature, NY, 2019 Kontzias A & Efthimiou P, Editors, Textbook, Case Studies in Autoinflammatory Disease, Springer-Nature, NY, 2020 (est)